The carcinogenic action of benzidine

An Integrated Concept of Carcinogenic- Anticarcinogenic Action

Toxicology and carcinogenic action of pyrrolizidine alkaloids.

The studies of the hepatoxic and hepatocarcinogenic pyrrolizidine alkaloids (PA) have shown that (a) The conventional testing for toxicity and its evaluation on the basis of death occurring a few days after dosing is meaningless for carcino genic agents, (b) A single dose of a water-soluble substance, the main part of which is metabolized and excreted in a few hours after ingestion and which do...

Benzidine and Dyes Metabolized to Benzidine

CARCINOGENICITY Benzidine................................................................................................3 Properties..................................................................................................................................4 Use ...................................................................................................................................

On the Mechanism of Action of Carcinogenic Substances*

In the study of cancer one of the central problems is the elucidation of the pathogenesis of malignant tumors. The direction taken by such studies varies in accordance with prevailing points of view on the etiology of cancer. Since the discovery of carcinogenic compounds by Cook, Kennaway, and others ( i , 7), the theory of a chemical etiology of malignant tumors has been advanced. According to...

Insights into the carcinogenic mode of action of arsenic.

That arsenic can induce cancer in humans has been known since the late 17th century, yet how arsenic induces cancer has been the subject of numerous scientific publications. Various modes of action (MOA) have been proposed for arsenic's carcinogenicity. In this paper we review our previous studies on the ability of arsenicals to cause DNA damage, the relative inability of these arsenicals to in...